Understanding ENHERTU: A Comprehensive Guide to Treatment Options – Pharmahub
In the realm of cancer treatment, ENHERTU has emerged as a promising prescription medicine, offering hope to individuals facing specific types of breast cancer, non-small cell lung cancer, and stomach cancer. This blog post delves into ENHERTU, its approved uses, administration, potential side effects, and more, providing a comprehensive guide for those seeking information about this innovative treatment.
What is ENHERTU?
ENHERTU is a prescription medicine designed to treat various forms of cancer, particularly:
- HER2-Positive Breast Cancer: For cases that cannot be removed by surgery or have metastasized and where prior anti-HER2 breast cancer treatment has been administered.
- HER2-Low Breast Cancer: In cases that cannot be removed by surgery or have metastasized with prior chemotherapy.
- HER2-Mutant Non-Small Cell Lung Cancer (NSCLC): For cases with a certain mutation in the HER2 gene, unrespectable by surgery or metastatic.
- HER2-Positive Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma: For locally advanced or metastatic cases after a prior trastuzumab-based regimen.
ENHERTU’s FDA approval is based on a clinical study measuring patient response rates and duration, with ongoing studies to confirm these results.
How is ENHERTU Administered?
Patients receive ENHERTU intravenously through an IV line, with a 21-day treatment cycle. The frequency and duration of treatment are determined by healthcare providers, who may adjust the infusion rate based on individual reactions. Medications to prevent nausea and vomiting are administered before the infusion.
In case of missed doses, prompt communication with healthcare providers is essential to reschedule appointments.
Possible ENHERTU Side Effects
While ENHERTU holds promise in cancer treatment, it can cause serious side effects, including:
- Nausea
- Low blood cell counts
- Fatigue
- Liver function abnormalities
- Hair loss
- Digestive issues (vomiting, constipation, diarrhea)
- Muscle or bone pain
- Decreased appetite
- Fertility concerns in males
Patients are encouraged to report any side effects promptly to their healthcare providers or contact the manufacturer.
Enhertu breast cancer treatment
Enhertu (chemical name: fam-trastuzumab-deruxtecan-nxki) is a targeted therapy. Enhertu works against unrespectable (not removable with surgery) and metastatic HER2-positive breast cancer that has been treated with an anti-HER2 medicine, as well as HER2-low breast cancer that has been treated with chemotherapy.
Dosage forms and strengths
For injection: 100 mg of fam-trastuzumab deruxtecan-nxki as a white to yellowish white lyophilized powder in a single dose vial for reconstitution and further dilution
Use in Specific Populations
- Pregnancy: ENHERTU can cause fetal harm when administered to a pregnant woman. Advise patients of the potential risks to a fetus. There are clinical considerations if Cancer Medicineis used in pregnant women, or if a patient becomes pregnant within 7 months after the last dose of ENHERTU.
- Lactation: There are no data regarding the presence of ENHERTU in human milk, the effects on the breastfed child, or the effects on milk production. Because of the potential for serious adverse reactions in a breastfed child, advise women not to breastfeed during treatment and for 7 months after the last dose.
- Females and Males of Reproductive Potential: Pregnancy testing: Verify pregnancy status of females of reproductive potential prior to initiation of ENHERTU. Contraception: Females: ENHERTU can cause fetal harm when administered to a pregnant woman. Advise females of reproductive potential to use effective contraception during treatment and for 7 months after the last dose. Males: Advise male patients with female partners of reproductive potential to use effective contraception during treatment and for 4 months after the last dose. Infertility: ENHERTU may impair male reproductive function and fertility.
- Pediatric Use: Safety and effectiveness of Cancer Medicinehave not been established in pediatric patients.
- Geriatric Use: Of the 883 patients with breast cancer treated with ENHERTU 5.4 mg/kg, 22% were ≥65 years and 3.6% were ≥75 years. No overall differences in efficacy within clinical studies were observed between patients ≥65 years of age compared to younger patients. There was a higher incidence of Grade 3-4 adverse reactions observed in patients aged ≥65 years (60%) as compared to younger patients (48%). Of the 101 patients with unrespectable or metastatic HER2-mutant NSCLC treated with Cancer Medicine 5.4 mg/kg, 40% were ≥65 years and 8% were ≥75 years. No overall differences in efficacy or safety were observed between patients ≥65 years of age compared to younger patients. Of the 125 patients with locally advanced or metastatic HER2-positive gastric or GEJ adenocarcinoma treated with Cancer Medicine 6.4 mg/kg in DESTINY-Gastric01, 56% were ≥65 years and 14% were ≥75 years. No overall differences in efficacy or safety were observed between patients ≥65 years of age compared to younger patients.
- Renal Impairment: A higher incidence of Grade 1 and 2 ILD/pneumonitis has been observed in patients with moderate renal impairment. Monitor patients with moderate renal impairment more frequently. The recommended dosage of ENHERTU has not been established for patients with severe renal impairment (CLcr <30 mL/min).
- Hepatic Impairment: In patients with moderate hepatic impairment, due to potentially increased exposure, closely monitor for increased toxicities related to the topoisomerase inhibitor. The recommended dosage of Cancer Medicine has not been established for patients with severe hepatic impairment (total bilirubin >3 times ULN and any AST).
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Conclusion
ENHERTU represents a significant advancement in cancer treatment, offering renewed hope to those facing challenging diagnoses. While it has shown promising results, ongoing research is crucial for further validation and improvement. Individuals considering or undergoing ENHERTU treatment should communicate openly with their healthcare providers, promptly reporting any concerns.
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